TACI Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. Two novel members in the TNF family were recently identified and designated BAFF/BLyS/TALL-1/THANK/zTNF4 and April/TALL-2, respectively. BAFF was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. April regulates immunological and non-immunological cell growth. Three receptors, BCMA, TACI, and BAFF-R, for BAFF and April were recently identified. TACI, like BCMA, binds BAFF and April. TACI and its ligands regulate humoral immune responses, activate NF-?B and c-jun N-terminal kinase, and are involved in B cell associated autoimmune diseases.
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Description
Western blot analysis of TACI in K562 (A) and U937 (B) cell lysates with TACI antibody at 5 ?g/mL.
Immunocytochemistry of TACI in K562 cells with TACI antibody at 2 ?g/mL.
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Specifications
Additional Names
TACI
Additional Names
TACI Antibody:
User Note
Optimal dilutions for each application to be determined by the researcher.
Isotype
IgG
Disclaimer
This product is for research use only.
Formulation
Physical State: Liquid?
Concentration: 1 mg/mL
Conjugate
None
Clonality/Clone
This is a polyclonal TACI Antibody.
Purification
TACI Antibody is affinity chromatography purified via peptide column.
Host
TACI antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
TACI antibody was raised against a synthetic peptide mapping at the amino terminus of human TACI.
Application
TACI polyclonal antibody can be used for detection of TACI by Western blot at 5 ?g/mL. Antibody can also be used for immunocytochemistry starting at 2 ?g/mL.
TACI Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat. No. ZP-2395 – TACI Peptide
Storage
TACI antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3
Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56
Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3
Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor-?B, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81 ]
