TL1A Antibody: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-?B activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI).
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Description
Western blot analysis of TL1A in mouse lung cell lysates with TL1A antibody at (A) 0.5, (B) 1, and (C) 2 ?g/mL.
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Specifications
Additional Names
TL1A
Additional Names
TL1A Antibody:
User Note
Optimal dilutions for each application to be determined by the researcher.
Isotype
IgG
Specificity
TL1A will not cross-react with TL1.
Disclaimer
This product is for research use only.
Formulation
Physical State: Liquid?
Concentration: 1 mg/mL
Conjugate
None
Clonality/Clone
This is a polyclonal TL1A Antibody.
Purification
TL1A Antibody is Antibody is DEAE purified.
Host
TL1A antibody was raised in rabbit.
Please use anti-rabbit secondary antibodies.
Immunogen
TL1A antibody was raised against recombinant human TL1A.
Application
TL1A antibody can be used for detection of TL1A by Western blot at 0.5 to 2 ?g/mL.
TL1A Antibody is supplied in PBS containing 0.02% sodium azide.
Blocking Peptide
Cat.No. ZP-3789 – TL1A Peptide
Storage
TL1A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Chinnayan AM, O?Rourke K, Yu GL, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274:990-2.
Kitson J, Raven T, Jiang YP, et al. A death-domain-containing receptor that mediates apoptosis. Nature 1996; 384:372-5.
Screaton GR, Xu XN, Olsen AL, et al. LARD: a new lymphoid-specific death domain containing receptor regulated by pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 1997; 94:4615-9.
Bodmer JL, Burns K, Schneider P. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95). Immunity 1997; 6:79-88.]
